Table 1. Time courses of transthoracic echocardiographic findings among five groups.
Variables | Group 1 (n=6) | Group 2 (n=6) | Group 3 (n=6) | Group 4 (n=6) | Group 5 (n=6) | p-value |
---|---|---|---|---|---|---|
Day 0 | ||||||
LVEDd (mm) | 34.91 ± 6.81 | 32.36 ± 5.0 | 34.0 ± 3.85 | 33.55 ± 7.0 | 35.90 ± 3.72 | 0.712 |
LVESd (mm) | 21.95 ± 4.92 | 20.76 ± 3.89 | 21.59 ± 1.70 | 20.68 ± 5.10 | 23.11 ± 2.87 | 0.531 |
LVEF (%) | 68.58 ± 3.67 | 67.04 ± 3.76 | 66.92 ± 3.69 | 67.39 ± 4.15 | 66.18 ± 2.96 | 0.882 |
Day 44* | ||||||
LVEDd (mm) | 34.41 ± 4.82a | 39.22 ± 2.31b | 39.96 ± 3.43b | 40.14 ± 3.24b | 38.18 ± 3.12b | <0.001 |
LVESd (mm) | 21.15 ± 2.92a | 28.09 ± 1.61b | 29.01 ± 1.62b | 28.98 ± 2.08b | 28.31 ± 1.96b | <0.001 |
LVEF (%) | 67.86 ± 3.67a | 55.36 ± 1.88b | 55.26 ± 4.76b | 57.84 ± 5.98b | 57.05 ± 2.80b | <0.001 |
Day 90† | ||||||
LVEDd (mm) | 35.56 ± 2.17a | 41.01 ± 5.18b | 40.78 ± 6.61b | 41.85 ± 3.46b | 38.92 ± 5.10b | <0.01 |
LVESd (mm) | 22.70 ± 1.89a | 30.82 ± 3.44b | 30.10 ± 4.43b | 31.39 ± 2.37b | 28.18 ± 3.50b | <0.001 |
LVEF (%) | 66.82 ± 3.29a | 50.27 ± 2.15b | 51.47 ± 4.13b | 50.77 ± 4.35b | 51.96 ± 4.09b | <0.001 |
Day 180 | ||||||
LVEDd (mm) | 36.26 ± 2.47a | 45.59 ± 2.62b | 45.43 ± 4.97b | 45.05 ± 2.76b | 46.23 ± 3.41b | <0.0001 |
LVESd (mm) | 23.21 ± 2.02a | 35.19 ± 4.43b | 36.38 ± 4.46b | 31.46 ± 1.61c | 32.17 ± 1.45c | <0.0001 |
LVEF (%) | 66.27 ± 3.72a | 45.03 ± 9.59b | 40.60 ± 5.05c | 59.61 ± 3.93d | 56.41 ± 2.79e | <0.0001 |
Data are expressed as mean ± SD or (%).
Group 1 = sham-operated control; group 2 = left ventricular ischemia (LVIs) by ameroid constrictor applied to left anterior descending artery; group 3 = LVIs + chronic kidney disease (CKD) by right nephrectomy and half (1/2) of the left renal artery ligation (i.e., LVIs + CKD); group 4 = LVIs + extracorporeal shock wave (ECSW); group 5 = LVIs + CKD + ECSW.
* indicated the timing was 44 days after CKD induction.
† indicated the ECSW was applied to groups 4 and 5 by day 90 after CKD induction.
LVEDd: left ventricular end-diastolic dimension; LVESd: left ventricular end-systolic dimension; LVEF: left ventricular ejection fraction.
Letters (a, b, c, d, e) indicate significant difference (at 0.05 level) by Tukey multiple comparison procedure.