Skip to main content
. 2017 Jul 5;8(33):55003–55021. doi: 10.18632/oncotarget.18991

Figure 4. Cobalt complex 2 dose-dependently inhibits cancer cell invasion.

Figure 4

(A) H1299 lung cancer cells seeded in the ECMatrixTM chamber were incubated with cobalt complex 2 for 72 h. The invaded H1299 cancer cells found in the lower layer of ECMatrixTM chamber were captured by digital camera under microscope with 40× magnifications. Bar chart represented the percentage of invasion ability of the stained invasive cells solute. Means ± S.D. were from three independent experiments. **P < 0.01 and ***P < 0.001 compared to DMSO control. (B) Cobalt complex 2 altered the expression of cell invasion markers in HeLa cancer cells. HeLa cells were treated with DMSO or indicated concentrations of cobalt complex 2 for 24 h. Cell lysates were harvested and analyzed by Western blot for Matrix metallopeptidase 9 (MMP-9), Intercellular Adhesion Molecule 1(ICAM-1) and β-actin.