Table 2. Collateral sensitivity of cobalt complexes 1–6 in taxol-resistant cancer cells.
| Cancer Types | IC50 value, μM | IC50 value, μM | Resistant Factor | |
|---|---|---|---|---|
| Taxol-sensitive cancer | Taxol-resistant cancer | |||
| MCF-7 | 12.2 | 55 | 4.51 | |
| Taxol | HCT-8 | 12.6 | >200 | >15.9 |
| A549 | 1.56 | 66.1 | 42.4 | |
| 1 | MCF-7 | 4.62 | 2.51 | 0.54 |
| HCT-8 | 3.13 | 1.16 | 0.37 | |
| A549 | 9.59 | 2.37 | 0.25 | |
| 2 | MCF-7 | 4 | 2.71 | 0.68 |
| HCT-8 | 3.39 | 1.22 | 0.36 | |
| A549 | 11.5 | 2.85 | 0.25 | |
| 3 | MCF-7 | 13.4 | 16.8 | 1.25 |
| HCT-8 | 11.4 | 7.78 | 0.68 | |
| A549 | 29.9 | 7.85 | 0.26 | |
| 4 | MCF-7 | 8.02 | 5.01 | 0.62 |
| HCT-8 | 18.5 | 10.2 | 0.55 | |
| A549 | 51.7 | 11.1 | 0.21 | |
| 5 | MCF-7 | 9.45 | 6.28 | 0.66 |
| HCT-8 | 4.3 | 1.04 | 0.24 | |
| A549 | 15 | 2.85 | 0.19 | |
| 6 | MCF-7 | 28.5 | 11.1 | 0.39 |
| HCT-8 | 56.4 | 41.1 | 0.73 | |
| A549 | 54.3 | 2.6 | 0.05 |