Table 3. Collateral sensitivity of cobalt complexes 1–6 in cisplatin-resistant cancer cells.
Cancer Types | IC50 value, μM | IC50 value, μM | Resistant Factor | |
---|---|---|---|---|
cisplatin-sensitive cancer | cisplatin-resistant cancer | |||
A2780 | 15.1 | > 200 | > 13.25 | |
Cisplatin | SGC-7901 | 3.92 | 43 | 10.97 |
OV2008 | 18.2 | – | > 11.0 | |
C13 | – | > 200 | ||
1 | A2780 | 11.9 | 11.2 | 0.94 |
SGC-7901 | 11.7 | 17.6 | 1.50 | |
OV2008 | 7.06 | – | 2.21 | |
C13 | – | 15.6 | ||
2 | A2780 | 12.3 | 10.7 | 0.87 |
SGC-7901 | 11.1 | 12.6 | 1.14 | |
OV2008 | 7.62 | – | 1.0 | |
C13 | – | 7.59 | ||
3 | A2780 | 28.8 | 31.6 | 1.10 |
SGC-7901 | 29.9 | 29.9 | 1.00 | |
OV2008 | 18.9 | – | 0.79 | |
C13 | – | 14.9 | ||
4 | A2780 | 55 | 54.1 | 0.98 |
SGC-7901 | 41.1 | 41.7 | 1.01 | |
OV2008 | 42.5 | – | 0.88 | |
C13 | – | 37.4 | ||
5 | A2780 | 24 | 27 | 1.13 |
SGC-7901 | 21.6 | 20.7 | 0.96 | |
OV2008 | 14 | – | 1.45 | |
C13 | – | 20.3 | ||
6 | A2780 | 30.2 | 29.1 | 0.96 |
SGC-7901 | 36.3 | 35.9 | 0.99 | |
OV2008 | 49.4 | – | 1.87 | |
C13 | – | 92.6 |