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. 2017 Jul 5;8(33):55003–55021. doi: 10.18632/oncotarget.18991

Table 3. Collateral sensitivity of cobalt complexes 1–6 in cisplatin-resistant cancer cells.

Cancer Types IC50 value, μM IC50 value, μM Resistant Factor
cisplatin-sensitive cancer cisplatin-resistant cancer
A2780 15.1 > 200 > 13.25
Cisplatin SGC-7901 3.92 43 10.97
OV2008 18.2 > 11.0
C13 > 200
1 A2780 11.9 11.2 0.94
SGC-7901 11.7 17.6 1.50
OV2008 7.06 2.21
C13 15.6
2 A2780 12.3 10.7 0.87
SGC-7901 11.1 12.6 1.14
OV2008 7.62 1.0
C13 7.59
3 A2780 28.8 31.6 1.10
SGC-7901 29.9 29.9 1.00
OV2008 18.9 0.79
C13 14.9
4 A2780 55 54.1 0.98
SGC-7901 41.1 41.7 1.01
OV2008 42.5 0.88
C13 37.4
5 A2780 24 27 1.13
SGC-7901 21.6 20.7 0.96
OV2008 14 1.45
C13 20.3
6 A2780 30.2 29.1 0.96
SGC-7901 36.3 35.9 0.99
OV2008 49.4 1.87
C13 92.6