Table 2. Stratification analysis of TCN2 c.230A>T according to CHD classification and phenotype.
| CHD Classification | Genotyping in Casesa | Genetic model | OR (95% CI)b | P-valueb |
|---|---|---|---|---|
| Septation defects | 251/142/17 | Codominant | NA | 0.001 |
| Dominant | 0.67 (0.51–0.89) | 0.005 | ||
| Recessive | 0.37 (0.21–0.68) | 0.001 | ||
| Additive | 0.77 (0.64–0.93) | 0.0004 | ||
| Conotruncal defects | 113/65/10 | Codominant | NA | 0.035 |
| Dominant | 0.70 (0.48–1.02) | 0.060 | ||
| Recessive | 0.41 (0.19–0.87) | 0.020 | ||
| Additive | 0.69 (0.57–0.93) | 0.014 | ||
| RVOTO | 36/21/3 | Codominant | NA | 0.290 |
| Dominant | 0.70 (0.40–1.22) | 0.206 | ||
| Recessive | 0.44 (0.13–1.48) | 0.185 | ||
| Additive | 0.70 (0.45–1.10) | 0.119 | ||
| PDA | 34/15/5 | Codominant | NA | 0.390 |
| Dominant | 0.66 (0.37–1.21) | 0.170 | ||
| Recessive | 0.86 (0.32–2.32) | 0.760 | ||
| Additive | 0.77 (0.49–1.21) | 0.250 |
aAA/AT/TT; bAdjusted by sex and age.