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. 2017 Jul 21;8(33):55230–55245. doi: 10.18632/oncotarget.19420

Figure 5. Cell viability as well as VEGF secretion after IL-6 signaling inhibition.

Figure 5

(A) Antihuman IL-6R antibody, tocilizumab (50 μg/ml), was used for the inhibition of IL-6 signaling. Cell count was determined by an MTT assay. Tocilizumab significantly increased susceptibility to TKIs, especially at low dosage of 5 μM for sorafenib, 1 μM for sunitinib and 1 and 5 μM for pazopanib. *p < 0.05 for two-tailed paired t-test compared with combination with tocilizumab and TKIs. (B) Tocilizumab inhibits low dosage TKI-induced VEGF expression, determined by ELISA. *p < 0.05 for two-tailed paired t-test compared with the TKI treated cells.