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. 2017 Jul 24;8(33):55353–55360. doi: 10.18632/oncotarget.19512

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Copyright: © 2017 Milione et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Confirmation that the SCYL3-NTRK1 fusion gene can be targeted by TRK inhibitors. (A) Comparison of anti-proliferation activities of 3 tyrosine kinase inhibitors in Ba/F3-SCYL3-NTRK1 cell line. (B) Western blot analysis of the changes in phosphorylation levels of TRKA and its downstream transducer PLCγ 2 hours post entrectinib and crizotinib treatment in Ba/F3-SCYL3-NTRK1 cells. (C) Cell cycle analysis of Ba/F3-SCYL3-NTRK1 treated with 3 and 10 nM of entrectinib for 18 hours compared to untreated cells. (D) Relative caspase 3/7 activities in Ba/F3-SCYL3-NTRK1 cells treated with increasing concentrations of entrectinib over time.