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. 2017 Jul 15;8(33):55422–55434. doi: 10.18632/oncotarget.19268

Figure 1. Resveratrol decreased age-dependent spontaneous tumorigenesis and increased protein level of SIRT1 in fish liver.

Figure 1

(A) Histological observations in liver at 12-month-old. Dotted areas indicated the spontaneous neoplasms. Scale bar = 30 mm. CONT: control group, RES: resveratrol group. (B, C) Positive immunohistochemical reaction to mutant anti-p53 antibody in hepatic neoplasms. Scale bar = 50 mm (n = 3 in each group). (D) Malignant degree of neoplasms in 9- and 12-month-old fish. (E, F) Activities of serum hepatic marker enzymes (AST and ALT) at three developmental stages (n = 6 in each group). White: CONT group; black: RES group. (G, H) SIRT1 expression was detected by immunoblot and immunohistochemical staining. Scale bar = 50 mm (n = 3 in each group). Data were presented as mean±SD. *p <0.05, **p <0.01.