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. 2017 Jul 15;8(33):55422–55434. doi: 10.18632/oncotarget.19268

Figure 2. Resveratrol inhibited proliferation by SIRT1-mediated post-translational modulations of K-Ras.

Figure 2

(A, B) Expression of PCNA and K-Ras measured by immunoblot at 9- and 12-month-old (n = 3 in each group). (C-F) Immunohistochemical analysis for PCNA, K-Ras, PI3K and p-AKT at 9- and 12-month-old (n = 3 in each group). (G) Interaction of K-Ras and SIRT1 at 6-month-old (n = 5 in each group). (H) Effects of resveratrol on acetylation of K-Ras (Ac-Lys) at 12-month-old (n = 5 in each group). Scale bar = 50 mm. Data were presented as mean±SD. *p <0.05.