Figure 5. Resveratrol induced apoptosis by up-regulation of DLC1 and interaction between DLC1 and SIRT1, and dephosphorylation of DLC1 with SIRT1 up-regulation.

(A) DLC1 expression at 9- and 12-month-old (n = 3 in each group). (B, C) Effects of resveratrol on interaction of DLC1 and SIRT1 at 9-month-old (n = 10 in each group). (D) Effects of resveratrol on phosphorylation of DLC1 (PAS) at 9-month-old (n = 5 in each group). (E) Levels of Bcl-2, Bax, cleaved capsase-3/7/9 at 12-month-old (n = 3 in each group). Data were presented as mean±SD. *p <0.05, **p <0.01.