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. 2017 Jun 21;8(33):55489–55510. doi: 10.18632/oncotarget.18590

Table 2. Characteristics of articles with Kaplan-Meier survival curves in gastric cancer.

miRNA Study Country Study design Sample Number Stage Cut-off Method Follow-up (month) Result HR(L/H) HR(H/L) 95%CI
20a Osawa S, 2011 [3] Japan R FFPE 37 II-III 70% qRT-PCR 60 OSu 1.93 0.48-7.87
20a Wang M, 2012 [5] China R Plasma 65 I-IV 0.26 RT-qPCR 36 OSm 1.58 1.10-2.25
20a Wu Q, 2013 [11] China R FFPE 97 None Median qRT-PCR 66 OSm 1.01 1.00-1.02
20b Katada T, 2009 [12] Japan R Frozen 42 None None qRT-PCR 60 OSm 2.01 0.59-6.85
20b Osawa S, 2011 [3] Japan R FFPE 34 II-III 70% qRT-PCR 60 OSu 1.21 0.20-7.23
20b Xue TM, 2015 [13] China R Tissue 102 I-IV Median RT-qPCR 75 OSm 3.32 1.20-9.14
21-5p Park SK, 2016 [14] Korea R FFPE 50 III ROC qRT-PCR 168 RFSu 2.05 1.26-3.34
21 Jiang J, 2011 [15] China R FFPE 55 III-IV None qRT-PCR 17 OSu 5.88 2.22-16.67
21 Osawa S, 2011 [3] Japan R FFPE 33 II-III 70% qRT-PCR 60 OSu 2.58 0.34-19.79
21 Xu Y, 2012 [16] China R Frozen 86 I-IV 5.12 qRT-PCR 36 OSu 1.15 0.59-2.25
21 Hirata K, 2013 [17] Japan P Tissue 61 None 3.58 IHC 42 RFSu 0.82 0.27-2.43
21 Komatsu S, 2013 [6] Japan R Plasma 69 I-IV 0.03 qRT-PCR 40 CSSm 13.39 1.72-104.42
21 Song J, 2013 [18] China R Serum 103 I-IV 0.64 qRT-PCR 54 OSu 0.99 0.48-2.07
21 Wang D, 2015 [19] China R Tissue 50 I-IV ROC qRT-PCR 12 OSu 1.89 1.17-3.07
27b Liu HT, 2015 [32] China R FFPE 103 I-IV None qRT-PCR 66 OSu 0.80 0.46-1.41
27b Shang Y, 2016 [33] China R Tissue 114 I-IV None ISH 84 OSu 1.61 0.92-2.80
27b Liu HT, 2017 [34] China R FFPE 102 I-IV Median RT-qPCR 67 OSm 1.33 0.60-2.98
34a Osawa S, 2011 [3] Japan R FFPE 37 II-III 70% qRT-PCR 60 OSu 0.20 0.06-0.68
34a Hui WT, 2015 [38] China R Frozen 76 I-III Mean qRT-PCR >60 OSm 2.33 1.10-4.93
34a Wei B, 2015 [39] TCGA R Tissue 157 I-IV X-tile Downloaded >100 OSu 2.31 0.13-40.12
34a Zhang H, 2015 [40] China R Frozen 137 I-IV 2.44 qRT-PCR 68 OSm 1.33 1.14-1.61
34a Yang B, 2016 [41] China R Tissue 50 I-IV Median qRT-PCR 60 OSu 3.05 0.60-15.50
106b Osawa S, 2011 [3] Japan R FFPE 37 II-III 70% qRT-PCR 60 OSu 2.70 0.43-17.06
106b Komatsu S, 2013 [6] Japan R Plasma 69 I-IV 0.05 qRT-PCR 40 CSSu 1.22 0.52-2.84
106b Yang TS, 2014 [45] China R Tissue 120 None Median qRT-PCR 45 OSu 1.79 1.10-2.90
107 Li X, 2011 [46] China R FFPE 50 None 90.95 qRT-PCR 48 OSu 0.48 0.28-0.82
107 Osawa S, 2011 [3] Japan R FFPE 37 II-III 70% qRT-PCR 60 OSu 4.09 1.26-13.32
107 Inoue T, 2012 [47] Japan R Frozen 161 I-IV 2.74 RT-qPCR 60 OSm 2.21 1.18-4.61
125a-3p Hashiguchi Y, 2012 [49] Japan R Frozen 70 I-IV 7.42 RT-qPCR 147.6 OSu 3.01 1.26-7.20
125a-5p Nishida N, 2011 [50] Japan R Frozen 87 I-IV None RT-qPCR 147.6 OSu 2.16 0.96-4.86
125a Dai J, 2015 [51] China R FFPE 73 I-IV None qRT-PCR 62 OSu 1.31 0.54-3.18
137 Gu Q, 2015 [62] China Set IChina Set II R Frozen 6787 I-III Median qRT-PCR 96 OSm
OSm 		6.802.41 2.06-22.481.13-5.11
137 Zheng X, 2015 [63] China R FFPE 38 I-IV Median qRT-PCR 56 DFSu 2.70 1.18-6.17
137 Du Y, 2016 [64] China R Tissue 14 I-IV 0.01 qRT-PCR 96 OSu 2.49 0.32-19.59
141 Lu YB, 2015 [65] China R Frozen 95 I-IV Median qRT-PCR 60 OSm 2.97 1.30-10.00
141 Zhou X, 2015 [66] China R Frozen 63 IIB-IV Median qRT-PCR >30 DFSu 2.47 1.22-5.00
141 Huang M, 2016 [67] China R Frozen 30 I-IV None qRT-PCR 26.83 OSu 2.23 1.04-4.79
143 Osawa S, 2011 [3] Japan R FFPE 37 II-III 70% qRT-PCR 60 OSu 2.95 0.19-46.23
143 Naito Y, 2014 [69] Japan R Frozen 66 I-IV 1/3 qRT-PCR 50 CSSm 2.62 1.21-5.80
143 Li JH, 2016 [70] China R Frozen 44 I-IV 1.18 qRT-PCR 26 OSu 0.40 0.23-0.70
145-5p Zhang Y, 2016 [72] China R Frozen 145 I-IV None RT-qPCR 66 OSm 3.87 1.13-11.44
145-5p Li CY, 2017 [56] TCGA R Tissue 361 I-IV None Downloaded 60 OSu 1.37 1.08-1.74
145 Naito Y, 2014 [73] Japan R FFPE 71 I-IV Median qRT-PCR 66.67 CSSm 0.71 0.33-1.49
145 Liu HT, 2017 [34] China R FFPE 102 I-IV Median RT-qPCR 67 OSu 1.68 0.87-3.25
146a Kogo R, 2011 [74] Japan R Frozen 90 I-IV Median qRT-PCR 132 OSu 2.20 1.31-3.70
146a Hou Z, 2012 [75] China R FFPE 30 I-IV 0.34 qRT-PCR 36 OSu 2.59 1.24-5.39
146a Luo Z, 2017 [76] China R Frozen 93 III-IV ROC RT-qPCR 72 OSu 7.75 1.66-35.71
150-5p Yoon SO, 2016 [77] Korea R FFPE 140118 I-IV 2.00 RT-qPCR 101.8 OSm
RFSu 		0.881.84 0.37-2.090.98-3.43
150 Katada T, 2009 [12] Japan R Frozen 42 None None qRT-PCR 60 OSm 6.10 0.76-50.00
150 Smid D, 2016 [79] Czech R FFPE 4140 None 6.006.70 qRT-PCR >100 OSu
PFSu 		1.912.08 1.14-3.211.11-3.91
183-5p Li CY, 2017 [56] TCGA R Tissue 361 I-IV None Downloaded 60 OSu 0.64 0.47-0.87
183 Cao LL, 2014 [83] China R Frozen 52 I-IV 3.55 qRT-PCR 60 OSu 2.83 1.31-6.10
183 Xu L, 2014 [84] China R Tissue 65 I-IV Median RT-qPCR 102 OSu 1.94 1.11-3.39
192 Chen Q, 2014 [48] China R Plasma 61 III-IV 2.00 qRT-PCR 43 OSm 0.89 0.39-2.04
192 Xu YJ, 2015 [87] China R Frozen 38 I-IV None qRT-PCR 81 OSu 0.99 0.96-1.02
192 Smid D, 2016 [79] Czech R FFPE 41 None 2.30 qRT-PCR >100 OSu 7.43 2.71-20.41
196a Sun M, 2012 [90] China R Frozen 31 II-IV 40.90 RT-qPCR 36 OSu 4.19 1.78-9.83
196a Mu YP, 2014 [88] China R Frozen 48 I-IV 5.69 qRT-PCR 60 OSu 2.88 1.43-5.79
196a Tsai MM, 2014 [91] China R Tissue 109 I-IV 77.30 qRT-PCR 60 OSu 2.27 1.50-3.43
196a Tsai MM, 2016 [92] China R Plasma 98 I-IV 1.15 qRT-PCR 72 OSm 3.06 1.10-8.50
196b-5p Li CY, 2017 [56] TCGA R Tissue 361 I-IV None Downloaded 60 OSu 2.07 1.37-3.13
196b Lim JY, 2013 [93] South Korea R Frozen 57 I-IV None qRT-PCR 75 OSu 1.50 1.06-2.12
196b Tsai MM, 2014 [91] China R Tissue 109 I-IV 21.70 qRT-PCR 60 OSu 1.55 1.16-2.06
196b Tsai MM, 2016 [92] China R Plasma 98 I-IV 0.93 qRT-PCR 72 OSm 2.91 1.04-8.17
200c Valladares-Ayerbes M, 2012 [98] Spain R Blood 52 I-IV 62.4 qRT-PCR 54 OSm
PFSm 		0.450.44 0.22-0.920.21-0.92
200c Tang H, 2013 [96] China R Tissue 126 I-IV 2.00 qRT-PCR 58 OSu
DFSu 		2.291.83 1.38-3.811.15-2.92
200c Zhang HP, 2015 [99] China R Serum 98 I-IV Median qRT-PCR 60 OSm 0.25 0.10-0.37
200c Zhou X, 2015 [66] China R Frozen 63 IIB-IV Median qRT-PCR >30 DFSu 1.70 1.21-2.38
206 Yang Q, 2013 [104] China R Tissue 98 I-IV 2.40 RT-qPCR 139 OSm 2.56 1.13-5.82
206 Shi H, 2015 [105] China R Frozen 220 I-IV Median qRT-PCR 60 OSm 6.82 1.51-21.29
206 Hou CG, 2016 [106] China R Serum 150 I-III Median RT-qPCR 60 OSm 2.39 1.16-4.91
214 Ueda T, 2010 [1] Japan R Frozen 101 I-IV None qRT-PCR 102.33 OSm 2.70 1.30-5.61
214 Yang TS, 2013 [110] China R Frozen 120 I-IV None qRT-PCR 45 OSu 1.77 1.06-2.96
214 Wang YW, 2014 [111] China R FFPE 80 I-IV Median RT-qPCR 72 OSu 1.20 0.67-2.15
214 Liu HT, 2017 [34] China R FFPE 102 I-IV Median RT-qPCR 67 OSm 2.75 1.12-6.76
218 Tie J, 2010 [114] China R Frozen 40 I-IV 13.81 qRT-PCR 72 OSu 2.33 1.40-3.89
218 Xin SY, 2014 [115] China R Serum 68 I-IV None qRT-PCR 36 OSm 3.16 1.06-9.40
218 Wang XX, 2016 [116] China R Tissue 112 I-IV Median qRT-PCR 60 OSm 3.19 1.55-8.37
335 Yan Z, 2012 [127] China R Both 74 I-IV None RT-qPCR 108 OSu 0.14 0.04-0.49
335 Yang B, 2016 [41] China R Tissue 50 I-IV Median qRT-PCR 60 OSu 4.88 1.90-12.55
335 Zhang JK, 2017 [128] China R Frozen 221 I-IV Median qRT-PCR 60 DFSu 1.65 1.11-2.45
451 Ren C, 2016 [4] China R FFPE 180 I-IV None ISH 97.2 OSm 2.01 1.36-2.96
451 Bandres E, 2009 [141] Spain R FFPE 45 I-III Median qRT-PCR 172 OSu
DFSm 		2.023.70 0.76-5.381.57-8.70
451 Brenner B, 2011 [142] Israel R FFPE 45 I-III Median qRT-PCR 50 RFSu 0.05 0.01-0.29
451 Su Z, 2015 [143] China R FFPE 107 I-IV Mean qRT-PCR 72 OSu 1.08 0.53-2.19
486-5p Li CY, 2017 [56] TCGA R Tissue 361 I-IV None Downloaded 60 OSu 1.85 1.22-2.81
486-5p Chen H, 2015 [147] China R FFPE 84 I-IV None ISH 75 OSm 3.61 1.99-6.54
486-5p Ren C, 2016 [148] China R FFPE 84 I-IV None ISH 93.6 OSm 2.55 1.39-4.69
506 Deng J, 2015 [154] China R Frozen 63 None None qRT-PCR >60 OSu 3.05 1.19-7.79
506 Li Z, 2015 [155] China R Frozen 84 I-IV Mean qRT-PCR >60 OSu 1.76 0.73-4.27
506 Sakimura S, 2015 [156] Japan R Tissue 141 I-IV Median qRT-PCR >140 OSm 1.90 1.05-3.59

HR (L/H): hazard ratios of low expression versus high expression of miRNAs; HR (H/L): hazard ratios of high expression versus low expression of miRNAs; CI: confidence intervals; TCGA: The Cancer Genome Atlas; R: retrospective; P: prospective; FFPE: formalin-fixed paraffin-embedded; ROC: receiver operating characteristic; qRT-PCR: quantitative real-time polymerase chain reaction; RT-qPCR: reverse transcription quantitative real-time polymerase chain reaction; IHC: immunohistochemistry; ISH: in-situ hybridization; OS: overall survival; RFS: recurrence-free survival; CSS: cause-specific survival; DFS: disease-free survival; PFS: progression-free survival; uUnivariate analysis; mMultivariate analysis. In order to facilitate read and statistics, studies estimating prognostic value of different miRNAs are shown in blue and white; studies which cannot be merged are shown in yellow.