Table 4. Summary of miRNAs with altered expression, their potential targets and pathways entered this study.
| miRNA | Reference | Expression | Potential target | Pathway |
|---|---|---|---|---|
| 20a | 3,5,11 | Up | E2F1, HIPK1 | Cell differentiation, proliferation, self-renewal and Wnt/β-catenin signaling |
| 20b | 3,12,13 | Up | None | None |
| 21 | 3,6,14-19 | Up | None | None |
| 27b | 32-34 | Down | CCNG1, VEGF-C | Cell migration and proliferation |
| 34a | 3,38-41 | Down | MET, Survivin | Cell apoptosis, colony formation, invasion and proliferation |
| 106b | 3,6,45 | Up | PTEN | Cell invasion and migration |
| 107 | 3,46,47 | Up | DICER1 | Cell invasion and migration |
| 125a | 49-51 | Down | VEGF-A, ERBB2 | Cell proliferation |
| 137 | 62-64 | Down | KLF12, MYO1C, CDK6 | Cell cycle, differentiation, migration and proliferation |
| 141 | 65-67 | Down | ZEB1/2, E-cadherin, IGF1R | Cell colony formation, cycle, invasion, migration, viability and TGF-β/ZEB signaling |
| 143 | 3,69,70 | Down | BACH1 | Cell invasion, proliferation and TGF-β/Mad signaling |
| 145 | 34,56,72,73 | Down | α-SMA | None |
| 146a | 74-76 | Down | EGFR, IRAK1, LIN52 | Cell apoptosis, invasion, migration and proliferation |
| 150 | 12,77,79 | Up | None | None |
| 183 | 56,83,84 | Down | EZR, BMI1 | Cell colony formation, invasion and proliferation |
| 192 | 48,79,87 | Up | None | Cell invasion |
| 196a | 88,90-92 | Up | CDKN1B, Rdx | Cell colony formation, cycle, invasion, migration and proliferation |
| 196b | 56,91-93 | Up | Rdx | Cell invasion and migration |
| 200c | 98,9966,96 | Up (blood)Down (tissue) | ZEB1/2, E-cadherin | Cell invasion, migration and TGF-β/ZEB signaling |
| 206 | 104-106 | Down | None | None |
| 214 | 1,34,110,111 | Up or Down | CSF1, PTEN | Cell invasion, migration and proliferation |
| 218 | 114-116 | Down | ROBO1 | Cell invasion and sli/ROBO1 signaling |
| 335 | 41,127,128 | Down | Survivin, BIRC5, CRKL | Cell apoptosis, cycle, growth, invasion, migration and proliferaion |
| 451 | 4,141-143 | Up or Down | MIF | Cell invasion, migration and proliferation |
| 486-5p | 56,147-148 | Down | FGF9 | None |
| 506 | 154-156 | Down | Yap1, ETS1, SNAI2 | Cell epithelial-mesenchymal transition, growth, invasion, migration and proliferation |
E2F1: E2F transcription factor 1; HIPK1: homeodomain interacting protein kinase 1; CCNG1: cyclin G1; VEGF: vascular endothelial growth factor; PTEN: protein tyrosine phosphatase and tensin homologue; DICER1: dicer 1, ribonuclease type III; ERBB2: erb-b2 receptor tyrosine kinase 2; KLF12: krűppel-likefactor 12; MYO1C: myosin 1C; ZEB1/2: zinc finger E-boxbinding homeobox 1/2; IGF1R: insulin-like growth factor 1 receptor; BACH1: BTB domain and CNC homolog 1; α-SMA: α smooth muscle actin; EGFR: epidermal growth factor receptor; IRAK1: interleukin 1 receptor associated kinase 1; LIN52: lin-52 homolog (C. elegans); EZR: ezrin; BMI1: BMI1 proto-oncogene, polycomb ring finger; CDKN1B: cyclin dependent kinase inhibitor 1B; Rdx: radixin; CSF1: colony stimulating factor 1; Robo1: roundabout guidance receptor 1; BIRC5: baculoviral IAP repeat containing 5; CRKL: CRK like proto-ongogene, adaptor protein; MIF: macrophage migration inhibitory factor (glycosylation-inhibiting factor); FGF9: fibroblast growth factor 9; YAP1: Yes associated protein 1; ETS1: ETS proto-oncogene 1, transcription factor; SNAI2: snail family transcriptional repressor 2; TGF-β: transforming growth factor-β; Mad: mothers against dpp; AKT1: AKT serine/threonine kinase 1; sli: slit.