Table 12. Summary of HIEPC-related procedures in different PC institutions or countries (published researches).
| Country /No. Institutions |
Major Institutions | No. patients | Mode | HIPEC-MMC alone | HIPEC-MMC+DDP | HIPEC-L-OHP alone | HIPEC-other | Temperature (°C) |
Duration (min) |
|---|---|---|---|---|---|---|---|---|---|
| USA, 17 | St. John Hospital [29, 72] | ||||||||
| Subtotal/Median/Range | ? | O/C | Y | Y | 40-43 | 30-120 | |||
| Tufts Medical Center [29, 72] | |||||||||
| Subtotal/Median/Range | ? | O/C | Y | Y | 40-43 | 30-120 | |||
| University of Illinois [29, 72] | |||||||||
| Subtotal/Median/Range | ? | O/C | Y | Y | 40-43 | 30-120 | |||
| University of Miami [29, 72] | |||||||||
| Subtotal/Median/Range | ? | O/C | Y | Y | 40-43 | 30-120 | |||
| American Society of Peritoneal Surface Malignancies (ASPSM) [29] | ? | NR | Y | Y | others | NR | NR | ||
| Mount Sinai Medical Center [78] | 51 | C | 40 mg | 41-43 | 90 | ||||
| Sharp Health Care [13] | ? | O/C | Y | Y | Y | MMC+CPT-11, 5-FU | 40-43 | 30-90 | |
| Subtotal | >1061 | C | 30/40 mg 10-20 mg/m2 10 or 12.5 mg/m2 |
Y, 200 mg/m2 | MMC+CPT-11, 5-FU | 42 (40-43) | 90 (60-90) /30 | ||
| France, 14 | Centre Hospitalo-Universitaire Lyon Sud [14, 16, 21, 29, 13, 40, 42, 53, 72, 101] | ||||||||
| Subtotal/Median/Range | >500 | C | 10 mg/L 0.7 mg/kg 40-60 mg 30-50 mg/m2 |
30-50 mg/m2 + 50-100 mg/m2 | 360 mg/m2 360-460 mg/m2 |
MMC+CPT-11, 5-FU MMC (0.7 mg/kg) + CPT-11 (100 mg/m2) L-OHP (360-460 mg/m2) + CPT-11 (100-200 mg/m2) |
44 (46-48) /43 | 90 (60-90) /30 | |
Note: C: closed abdomen technique for HIPEC; O: open abdomen technique for HIPEC; Y: yes; MMC: mitomycin C; DDP: cisplatin; 5-FU: fluorouracil; L-OHP: oxaliplatin; CPT-11: irinotecan