Table 13. Summary of HIEPC-related procedures in different PC institutions or countries (published researches).
| Country /No. Institutions |
Major Institutions | No. patients | Mode | HIPEC-MMC alone | HIPEC-MMC+DDP | HIPEC-L-OHP alone | HIPEC-other | Temperature (°C) |
Duration (min) |
|---|---|---|---|---|---|---|---|---|---|
| France, 14 | Gustave Roussy Institute [13, 14, 28, 35, 36, 49, 50, 54, 73, 99-101] | ||||||||
| Subtotal/Median/Range | >700 | O | 5, 8, or 10 mg/L 20 mg/m2 12.9+/-3.8 mg/m2 30-50 mg/m2 |
20 mg/m2 + 200 mg/m2 30-50 mg/m2 + 50-100 mg/m2 |
460 mg/m2 360-460 mg/m2 |
MMC+CPT-11, 5-FU L-OHP (360-460 mg/m2) + CPT-11 (100-200 mg/m2) L-OHP (300 mg/m2) + CPT-11 (200 mg/m2) |
43 (41-44) /43 | 60 (60-90) /30 | |
| Val d’Aurelle Center [13, 14, 54, 73] | |||||||||
| Subtotal/Median/Range | >66 | O | 30-50 mg/m2 | 30-50 mg/m2 + 50-100 mg/m2 | 460 mg/m2 360-460 mg/m2 |
L-OHP (360-460 mg/m2) + CPT-11 (100-200 mg/m2) L-OHP (300 mg/m2) + CPT-11 (200 mg/m2) |
43.5 (40-43) /43 | 60 (60-90) /30 | |
| Centre Hospitalo-Universitaire l’Archet [13, 14, 54] | |||||||||
| Subtotal/Median/Range | >25 | O/C | 30-50 mg/m2 | 30-50 mg/m2 + 50-100 mg/m2 | 360-460 mg/m2 | L-OHP (360-460 mg/m2) + CPT-11 (100-200 mg/m2) | 41.5 (41-43) /43 | 60 (60-90) /30 or 60 | |
| Paul Papin Institute [13, 14, 54] | |||||||||
| Subtotal/Median/Range | >25 | O/C | 30-50 mg/m2 | 30-50 mg/m2 + 50-100 mg/m2 | 360-460 mg/m2 | L-OHP (360-460 mg/m2) + CPT-11 (100-200 mg/m2) | 41.5 (41-43) /43 | 60 (60-90) /30 or 60 | |
| French Association of Surgery [14, 54] | |||||||||
| Subtotal/Median/Range | ? | O/C | 30-50 mg/m2 | 30-50 mg/m2 + 50-100 mg/m2 | 360-460 mg/m2 | L-OHP (360-460 mg/m2) + CPT-11 (100-200 mg/m2) | 41 (41-43) /43 | 90 (60-120) /30 or 60 | |
Note: C: closed abdomen technique for HIPEC; O: open abdomen technique for HIPEC; Y: yes; MMC: mitomycin C; DDP: cisplatin; 5-FU: fluorouracil; L-OHP: oxaliplatin; CPT-11: irinotecan