Table 15. Summary of HIEPC-related procedures in different PC institutions or countries (published researches).
| Country /No. Institutions |
Major Institutions | No. patients | Mode | HIPEC-MMC alone | HIPEC-MMC+DDP | HIPEC-L-OHP alone | HIPEC-other | Temperature (°C) |
Duration (min) |
|---|---|---|---|---|---|---|---|---|---|
| Italy, 8 | Regina Elena National Cancer Institute [13, 46] | ||||||||
| Subtotal/Median/Range | >25 | O/C | Y | 3.3 mg/m2/L + 25 mg/m2/L | 460 mg/m2 | MMC+CPT-11, 5-FU | 42 (41.5-43) /43 | 60 (60-90) /30 | |
| University of Padua [46, 71] | |||||||||
| Subtotal/Median/Range | >46 | O/C | 3.3 mg/m2/L | 3.3 mg/m2/L + 25 mg/m2/L | 460 mg/m2 | 42 (41.5-43) /43 | 90 (60-90) /33 | ||
| Istituto Nazional Tumori [13] | 25 | O/C | Y | Y | Y | MMC+CPT-11, 5-FU | 40-43 | 30-90 | |
| Ospedale di Bentivoglio [46] | ? | O/C | 3.3 mg/m2/L + 25 mg/m2/L | 460 mg/m2 | 41.5-43/43 | 60-90/30 | |||
| San Camillo-Forlanini Hospital [46] | ? | O/C | 3.3 mg/m2/L + 25 mg/m2/L | 460 mg/m2 | 41.5-43/43 | 60-90/30 | |||
| San Giovanni Battista Antica Sede Hospital [92] | 25 | C | 15 mg/m2 | 42 | 60 | ||||
| Subtotal | >186 | C | Y | 3.3 mg/m2/L + 25 mg/m2/L | 460 mg/m2 | MMC+CPT-11, 5-FU | 42 (41.5-43) /43 | 60 (60-90) /30 | |
| Belgium, 6 | Jolimont Hospital [14,54, 58] | ||||||||
| Subtotal/Median/Range | ? | O | 30-50 mg/m2 | 30-50 mg/m2 + 50-100 mg/m2 | 360-460 mg/m2 460 mg/m2 |
L-OHP (360-460 mg/m2) + CPT-11 (100-200 mg/m2) | 41.5 (41-42.5) /43 | 90 (60-120) /30 or 60 | |
| Ghent University Hospital [47, 58] | |||||||||
| Subtotal/Median/Range | >152 | O | 35 mg/m2 | 460 mg/m2 | 41 (41-42) | 60 (60-90) /30 | |||
| University Hospitals Gasthuisberg [58, 59] | |||||||||
| Subtotal/Median/Range | >39 | O | 460 mg/m2 | 41-42 | 30 | ||||
Note: C: closed abdomen technique for HIPEC; O: open abdomen technique for HIPEC; Y: yes; MMC: mitomycin C; DDP: cisplatin; 5-FU: fluorouracil; L-OHP: oxaliplatin; CPT-11: irinotecan