Table 16. Summary of HIEPC-related procedures in different PC institutions or countries (published researches).
| Country /No. Institutions |
Major Institutions | No. patients | Mode | HIPEC-MMC alone | HIPEC-MMC+DDP | HIPEC-L-OHP alone | HIPEC-other | Temperature (°C) |
Duration (min) |
|---|---|---|---|---|---|---|---|---|---|
| Belgium, 6 | I-Biostat, Katholieke Universiteit Leuven and Universiteit Hasselt [58] | ? | O | 460 mg/m2 | 41-42 | 30 | |||
| UCL Mont-Godinne [58] | ? | O | 460 mg/m2 | 41-42 | 30 | ||||
| Ziekenhuis Oost-Limburg [58] | ? | O | 460 mg/m2 | 41-42 | 30 | ||||
| Subtotal | >191 | O | 30-50 mg/m2 | 30-50 mg/m2 + 50-100 mg/m2 | 460 mg/m2 | L-OHP + CPT-11 | 41 (41-42) /41-42 | 90 (60-90) /30 or 60 | |
| Netherlands, 6 | Netherlands Cancer Institute [12, 19,51, 59, 65, 66, 77, 89] | ||||||||
| Subtotal/Median/Range | 863 | O | 35 mg/m2 | 41.5 (41-42) | 90 | ||||
| Catharina Hospital Eindhoven [44, 63-65, 84, 85, 102] | |||||||||
| Subtotal/Median/Range | >300 | O | 35 mg/m2 | 41.5 (41-42) | 90 | ||||
| Sint Antonius Hospital Nieuwegein [44, 65, 84, 85] | |||||||||
| Subtotal/Median/Range | >121 | O | 35 mg/m2 | 41.5 (41-42) | 90 | ||||
| Radboud University Nijmegen Medical Center [64] | 12 | O | 35 mg/m2 | 41-42 | 90 | ||||
| University Medical Center Groningen [64] | 48 | O | 35 mg/m2 | 41-42 | 90 | ||||
| VU Medical Centre Amsterdam [64] |
17 | O | 35 mg/m2 | 41-42 | 90 | ||||
| Subtotal | >1432 | O | 35 mg/m2 | 41.5 (41-42) | 90 | ||||
| Spain 6 |
Hospital San Jaime [29, 71] | ||||||||
| Subtotal/Median/Range | ? | O/C | Y | Y | 40-43 | 30-120 | |||
| Hospital Torrecardenas [29, 71] | |||||||||
| Subtotal/Median/Range | ? | O/C | Y | Y | 40-43 | 30-120 | |||
Note: C: closed abdomen technique for HIPEC; O: open abdomen technique for HIPEC; Y: yes; MMC: mitomycin C; DDP: cisplatin; 5-FU: fluorouracil; L-OHP: oxaliplatin; CPT-11: irinotecan