Table 4. Major Characteristics of Fifteen Controlled Researches on Peritoneal Carcinomatosis (PC) from Colorectal Cancer (CRC) Treated with Cytoreductive Surgery (CRS) plus Hyperthermic Intraperitoneal Chemotherapy (HIPEC) versus Surgery alone with Systemic Chemotherapy (SC) and/or Early Postoperative Intraperitoneal Chemotherapy (EPIC).
| Author/ Year/ Country | Participating Institutions |
Study Period | Design | Level of Evidence | Number of CRC PC | Treatment strategy | |
|---|---|---|---|---|---|---|---|
| HIPEC group | Control group | ||||||
| Gervais MK/ 2013/ Canada [38] | 1 | 2004-2011 | retrospective | IIa | 40 (40/40) | Neoadjuvant SC with/without neoadjuvant radiotherapy+ CRS+HIPEC+SC 25 pts Neoadjuvant SC: BEV HIPEC: L-OHP (460 mg/m2) for 30 min between 42-44°C using the Coliseum technique; Before starting HIEPC, 5-FU (400 mg/m2) and LV (20 mg/m2) by intravenous perfusion. No EPIC SC: 5-FU, LV, L-OHP, and/or CPT-11, with or without BEV |
Neoadjuvant SC with/without neoadjuvant radiotherapy + surgery + SC 15 pts Neoadjuvant SC: BEV SC: 5-FU, LV, L-OHP, and/or CPT-11, with or without BEV No EPIC No HIPEC |
| Glehen O/ 2004/ France [13] | 28 (a central database) |
1987-2002 | retrospective | IIa | 506 (506/506) | CRS+HIPEC with/without SC 383 pts CRS+HIPEC with/without EPIC/SC 112 pts HIPEC: MMC/MMC+DDP, L-OHP, MMC+CPT-11, 5-FU, others during 30 to 90 min at 40-43°C using Coliseum or closed abdomen technique. EPIC: 5-FU (15 mg/kg/d) on Day 1-5 after surgery SC: 1. 5-FU + LV with/without DDP/L-OHP; 2. 5-FU alone; 3. 5-FU + LV+ L-OHP+ CPT-11; 4. Others and unknown |
CRS+EPIC with/without SC 235 pts EPIC: 5-FU (15 mg/kg/d) on Day 1-5 after surgery SC: 1. 5-FU + LV with/without DDP/L-OHP; 2. 5-FU alone; 3. 5-FU + LV+ L-OHP+ CPT-11; 4. Others and unknown No HIPEC |
| Goéré D/ 2015/ France [99] | 1 | 2000-2010 | retrospective | IIa | 139 (139/180) | Neoadjuvant SC +CRS+HIPEC+SC with/without EPIC 139 pts HIPEC: L-OHP+CPT-11 (72%), CPT-11 alone (15%), other items not reported. SC: 1. 5-FU + L-OHP; 2. 5-FU + CPT-11; 3. 5-FU alone EPIC: MMC/5-FU |
Neoadjuvant SC +Surgery+SC 41 pts SC: 1. 5-FU + L-OHP; 2. 5-FU + CPT-11; 3. 5-FU alone |
Note: CRC: colorectal cancer; PC: peritoneal carcinomatosis; Pts: patients; MMC: mitomycin C; DDP: cisplatin; FU: fluorouracil; LV: leucovorin; L-OHP: oxaliplatin; CPT-11: irinotecan; Cap: capecitabine; C225: cetuximab; CPT: camptothecin; BEV: bevacizumab; DXL: docetaxel; CBP: carboplatin; PAN: panitumumab;