Table 6. Major Characteristics of Sixty-one Single Arm Researches on Peritoneal Carcinomatosis (PC) from Colorectal Cancer (CRC) Treated with Cytoreductive Surgery (CRS) plus Hyperthermic Intraperitoneal Chemotherapy (HIPEC).
| Author/ Years/ Country | Participating Institutions |
Study Period | Design | Level of evidence | Number of CRC PC | HIPEC |
|---|---|---|---|---|---|---|
| Alzahrani/ 2015/ Australia [41] | 1 | 1996-2014 | retrospective | III | 205 (205/675) | Before HIPEC, 5-FU (400 mg/m2) were delivered by systemic i.v., L-OHP (350 mg/m2) for 30 min at 43°C using coliseum technique. |
| Beaujard/ 2000/ France [42] | 1 | 1991-1997 | prospective | IIb | 27 (27/86) | MMC (10 mg/L) for 90 min at inflow temperature 46-49 °C using the closed abdomen technique. |
| Bijelic/ 2008/ Australia [43] | 1 | 1981-2004 | retrospective | III | 70 (70/472) | MMC (10 mg/m2 for females and 12.5 mg/m2 for males) for 90 min at about 42 °C using the coliseum technique. |
| Braam/ 2014/ Australia [44] | 2 | 2005-2013 | retrospective | III | 132 (132/132) | MMC (17.5 mg/m2 an additional 8.8 mg/m2 at an interval of 30 and 60 min) for 90 min at 42 °C using the coliseum technique. |
| Cao/ 2009/ Australia [45] | 1 | 1995-2008` | retrospective | III | 52 (52/467) | MMC (10-12.5 mg/m2) for 90 min at 42 °C using coliseum technique. |
| Cavaliere/ 2006/ Italy [46] | 6 | 1996-2005 | retrospective | III | 120 (120/120) | MMC (3.3 mg/m2/L) + DDP (25 mg/m2/L) for 60-90 min at 41.5-43 °C using the coliseum or closed abdomen technique. After intravenous administration of 5-FU (400 mg/m2) and LV (20 mg/m2), L-OHP (460 mg/m2) for 30 min at 43 °C using the coliseum or closed abdomen technique. |
| Ceelen/ 2014/ Belgium [47] | 1 | 2002-2012 | retrospective | III | 152 (152/166) | Before HIPEC, LV (20 mg/m2) and 5-FU (400 mg/m2) were delivered by systemic i.v. L-OHP (460 mg/m2) or MMC (35 mg/m2) for 30-90 min at 41 °C using coliseum technique. |
| Desantis/ 2014/ France [48] | 1 | 1999-2011 | retrospective | III | 74 (74/356) | MMC (10 mg/m2 for females and 12.5 mg/m2 for males) for 90 min at 43°C using coliseum or closed abdomen technique. |
| Elias/ 2004/ France [49] | 1 | 1998-2001 | prospective | IIb | 24 (24/24) | One hour before HIPEC, LV (20 mg/m2) and 5-FU (400 mg/m2) were delivered by systemic i.v. HIPEC: L-OHP (460 mg/m2) for 30 min at 43 °C using the coliseum technique. |
| Elias/ 2014/ France [50] | 1 | 1995-2010 | retrospective | III | 119 (119/443) | MMC (5, 8, or 10 mg/L) for 1 h between 41 °C and 44 °C using the coliseum technique. MMC (20 mg/m2) + DDP (200 mg/m2) for 1 h between 41 °C and 44 °C using the coliseum technique. L-OHP 460 mg/m2 over 30 min at 43°C using the coliseum technique. MMC (12.9+/-3.8 mg/m2) for 90 min between 41 °C and 42 °C using closed abdomen technique. |
Note: MMC: mitomycin C; DDP: cisplatin; FU: fluorouracil; LV: leucovorin; L-OHP: oxaliplatin; CPT-11: irinotecan; NR: not reported