Table 1.
Main characteristics of the study population in subgroups of AKI/non-AKI and septic/non-septic patients
| Total | Non-AKI | AKI | p value | Non-septic | Septic | p value | |
|---|---|---|---|---|---|---|---|
| n | 98 | 49 | 49 | – | 58 | 40 | – |
| Men | 65 (66.3%) | 30 (61.2%) | 35 (71.4%) | NS | 38 (65.5%) | 27 (67.5%) | NS |
| Age (years) | 55 ± 17.3 | 50.4 ± 17.9 | 59.9 ± 15.5 | 0.006 | 50.9 ± 16.6 | 61.2 ± 16.8 | 0.003 |
| Renal characteristics | |||||||
| Baseline eGFR (mL/min) n = 86 | 110.6 ± 53.7 | 120.5 ± 60.5 | 100.7 ± 44.6 | NS | 121.9 ± 58.9 | 94.8 ± 41.2 | 0.020 |
| Baseline creatinine (μmol/L) n = 86 | 79 ± 31.5 | 80.5 ± 32.3 | 78.1 ± 31.1 | NS | 79.6 ± 28.9 | 78.9 ± 35.1 | NS |
| Creatinine upon ICU admission | 94.1 ± 42.2 | 74.6 ± 30.2 | 113.1 ± 43.9 | <0.001 | 85.0 ± 36.8 | 106.9 ± 46.5 | 0.015 |
| AKI at admission | 44 (44.9%) | – | 44 (89.8%) | – | 20 (34.5%) | 24 (60%) | 0.013 |
| AKIN ≥ 2 upon ICU admission | 25 (25.5%) | – | 25 (51%) | – | 9 (15.5%) | 16 (40%) | 0.009 |
| Renal replacement <48 h | 5 (5.1%) | 0 (0%) | 5 (10.2%) | 0.056 | 4 (6.9%) | 1 (2.5%) | NS |
| Worst value [TIMP-2]·[IGFBP7] ((ng/mL)2/1000) | 0.41 (0.20–1.36) | 0.24 (0.11–0.48) | 1.03 (0.38–3.29) | <0.001 | 0.36 (0.14–1.08) | 0.56 (0.26–2.94) | NS |
| ICU epidemiological data | |||||||
| Shock | 35 (35.7%) | 11 (22.5%) | 24 (50%) | 0.011 | 10 (17.2%) | 25 (62.5%) | <0.001 |
| Septic shock | 19 (19.4%) | 6 (12.3%) | 13 (26.5%) | NS | – | 19 (47.5%) | – |
| Mechanical ventilation | 79 (80.6%) | 39 (79.6%) | 40 (81.6%) | NS | 44 (75.9%) | 35 (87.5%) | NS |
| SAPS II | 37.4 ± 18.3 | 30.9 ± 14.9 | 43.9 ± 19.2 | <0.001 | 30.9 ± 15.6 | 46.8 ± 18.1 | <0.001 |
| APACHE II | 15.7 ± 8.2 | 13.5 ± 7.7 | 17.9 ± 8.2 | 0.007 | 14.2 ± 8.5 | 17.9 ± 7.3 | 0.024 |
| SOFA at ICU admission | 7.5 ± 3.7 | 6.1 ± 3.2 | 8.9 ± 3.7 | <0.001 | 6.7 ± 3.7 | 8.7 ± 3.4 | 0.009 |
| ICU LOS (days) | 11.1 ± 14.6 | 10.0 ± 10.6 | 12.3 ± 18.8 | NS | 9.3 ± 11.0 | 13.9 ± 18.5 | NS |
| Hospital LOS (days) | 23.6 ± 25.0 | 23.4 ± 23.3 | 23.8 ± 27.0 | NS | 21.4 ± 21.3 | 26.9 ± 29.6 | NS |
| ICU mortality | 10 (10.2%) | 4 (8.2%) | 6 (12.3%) | NS | 6 (10.3%) | 4 (10%) | NS |
Values expressed as either % per column, mean ± standard deviation or median and interquartile range. p value of statistical significance
NS no statistical significance, AKI acute kidney injury, AKIN acute kidney injury network definition, APACHE II acute physiology and chronic health evaluation II, ICU intensive care unit, LOS length of stay, SAPS II Simplified Acute Physiology Score II, SOFA sequential organ failure assessment score