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. 2017 Sep 7;7:10888. doi: 10.1038/s41598-017-09971-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clearance of intravenously administered fluorophores. Y-axis portrays urinary MB-402: MB-301 ratios in rats that had been gavage challenged with high-dose indomethacin or vehicle alone one day earlier (three challenged and three control rats). X-axis portrays timing of urine samples after intravenous injection of the fluorophores. Green and red dotted lines represent urinary ratios of individual challenged or individual control rats, respectively. Solid lines represent the corresponding arithmetic means of these ratios at each sampling. Letters correspond to the numbers for the same rats in Supplementary Fig. S3.