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. 2017 Sep 7;7:10788. doi: 10.1038/s41598-017-11315-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HUVEC response to FXa, thrombin and PAR agonist peptides. Fluo-4 –loaded HUVEC were stimulated by PAR-1 and PAR-2 agonists and fluorescence intensity readings recorded continuously for 10 minutes as described. Data are shown as representative traces of intracellular Ca²⁺ release upon stimulation with (A) Thrombin (10 nM); (B) FXa (150 nM) (C) PAR-1 agonist peptide TFLLR and PAR-2 agonist peptide SLIGKV. (D) Concentration-response curves in HUVECs following Thrombin (3–30 nM) and FXa (30–150 nM) stimulation.

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