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. 2017 Sep 7;7:10776. doi: 10.1038/s41598-017-11069-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Diet affects the impact of stress on activity in male mice. (a–c) After stress, males on HFD showed reduced locomotion activity compared to females on either diet. Males on NCD were not different from females, and the activity of females on the two diets was not different from each other. (d–f) In order to normalize for any differences that might be caused by performing the same behavioral tests twice in the same mice (separated by 7 weeks), post-stress results were divided by pre-stress results to obtain a ratio that was then compared between female and male mice and between mice on the different diets. The ratio of post/pre-stress activity was significantly less in males on HFD compared to NCD in the elevated plus maze (EPM). All graphs show Mean ± SE. Letters above bars indicate statistical significance (p < 0.05)—bars with the same letter are not significantly different from each other. N = 14–17 per group.