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. 2017 Sep 7;7:10934. doi: 10.1038/s41598-017-11405-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlations of PPP-associated miRNAs with IL-6. Relative expression of the miRNAs measured in the PPPs, normalised to CEL-miR-39 and PPP count, and IL-6 were log transformed and correlated using the nonparametric Spearman’s Correlation co-efficient. Data was considered significant with a p value < 0.05. (a) miR-122 and (b) miR-200a both significantly correlated with IL-6 while (c) the association with let-7e was not significant, but approached significance. (d) Levels of baseline IL-6 were significantly increased in liver cases compared to controls. Matching xy pairs were available for 30 individuals in the miR-122 analysis and 31 individuals in the miR-200a and let-7e analyses.