Figure 1.
In vivo therapeutic activity of L12P and L18R peptides. Groups of 16 Galleria mellonella larvae were infected with 5 × 105 cells of Candida albicans SC5314 and administered 1 h later (single injection, 10 μl) with peptides (12.5 mg/kg) or saline solution (control group). Larvae were then incubated at 37 °C in the dark for 9 days, and scored daily for survival.The survival curves of peptide-treated animals were significantly different from that of control group, as assessed by the log-rank (Mantel-Cox) test (**p = 0.0016, ***p = 0.0001). Data reported are from one representative experiment out of two experiments with comparable results.