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. 2017 Sep 7;7:10896. doi: 10.1038/s41598-017-11396-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transmission electron microscopy of Candida albicans cells treated with L12P and L18R peptides. Approximately 10⁷ yeast cells were incubated without (panels A–C, controls) or with the selected peptides (125 μg/ml) (panels D–F, cells treated with peptide L12P; panels G–I, cells treated with peptide L18R) for 60 min. Still intact cells treated with both peptides presented cytoplasmic changes with the presence of a number of microbodies (panels D,E,F,I), membrane retraction and cell wall alteration (panels D,F,G,H). Bar: 1000 nm (panels A,C,E), 500 nm (panels B,D,F–I).