Figure 1.

T1-weighted MRI and standardized result presentation for dataset P005, a MTLE-HS patient with left-sided seizure onset. In the top row three axial and two coronal slices are shown. The images are displayed according to “neurological” convention, i.e. the left side of the images corresponds to the left hemisphere. The gray-white matter interface found by FreeSurfer is displayed as a blue and the pial surface as a red line. Voxels corresponding to surface parcellations with abnormally high Gaussian curvature are highlighted with red-to-yellow coloring and voxels corresponding to reduced cortical thickness with blue-to-white coloring. The mean cortical thickness (middle row) was reduced in the left lateral occipito-temporal gyrus with and without eTIV normalization (p = 0.002). With odds of 17.2 the confidence in a valid (vs. artefactual) observation was high, especially after eTIV normalization. The corresponding structure on the right hemisphere and the asymmetry index were still within the normal range. The Gaussian curvature (bottom row) of the lateral aspect of the superior temporal gyrus was asymmetric (p = 0.005), with highly significantly increased curvature on the left (p < 10⁻⁶). Again, odds >8 gave confidence in reliable observations.