Table 1.
List of parameters used in this work, and best fit parameter values from models.
| Parameter | Meaning | Value |
|---|---|---|
| Charged particle model parameters – Fit in this work | ||
| E DSB | Average energy required to produce 1 DSB | 60.7 ± 14 keV |
| Cellular parameters – Fixed from mechanistic model 24 | ||
| DNA Repair Parameters | ||
| DNA Damage Yield | 5.738 DSB/Gy/Gbp | |
| λ F | Fast Repair Coefficient | 3.6 ± 0.6 hours−1 |
| λ S | Slow Repair Coefficient | 0.15 ± 0.02 hours−1 |
| λ M | MMEJ Repair Coefficient | 0.0084 ± 0.0015 hours−1 |
| p c | Complex break probability | 0.42 ± 0.03 |
| p f | Repair Failure Probability | 0.67 ± 0.09 |
| σ | Misrejoin range | 0.0428 ± 0.0005 Rnuc |
| μ NHEJ | NHEJ Fidelity | 0.985 ± 0.002 |
| μ MMEJ | MMEJ Fidelity | 0.465 ± 0.05 |
| Survival Parameters | ||
| ψ | Mitosis Sensitivity | 0.014 ± 0.002 break−1 |
| φ | Apoptosis Sensitivity | 0.0085 ± 0.001 break−1 |
All of the DNA repair and survival model parameters are taken from a previous publication without additional fitting24, while E DSB is obtained from a fit to proton data in this work.