Table 2.
Maternal complications of pregnancy.
| FRENCH COHORT | CANADIAN COHORT | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Underweight | Normal Weight | Overweight | Obesity | Underweight | Normal Weight | Overweight | Obesity | |||||
| Class I | Class II | Class III | Class I | Class II | Class III | |||||||
| Hypertensive disorders of pregnancy | 1303 (4.6) | 1629 (7.4)§ | ||||||||||
| n (%) | 64 (2.9)† | 657 (3.8) | 279 (5.6)† | 138 (8.3)† | 67 (12.3)† | 37 (14.7)† | 32 (5.9)§ | 618 (4.8)§ | 434 (8.4)†§ | 281 (13.0)†§ | 156 (18.1)†§ | 108 (21.4)†§ |
| Crude RR | 0.9 [0.7–1.1] | 1 | 1.6 [1.5–1.7] | 2.4 [2.2–2.6] | 3.3 [2.9–3.8] | 3.9 [3.4–4.5] | p interaction = 0.09 and 0.07 | |||||
| Adjusted RR** | 0.9 [0.7–1.2] | 1 | 1.4 [1.3–1.6] | 2.1 [1.9–2.4] | 2.6 [2.3–3.1] | 2.8 [2.3–3.3] | ||||||
| Adjusted RR obtained with fractional polynomials* | 0.7 [0.7–0.7] | 1 | 1.5 [1.5–1.6] | 2.2 [2.0–2.5] | 3.0 [2.7–3.4] | 3.5 [3.3–4.0] | ||||||
| Preeclampsiaα | 911 (3.2) | 697 (3.2) | ||||||||||
| n (%) | 49 (2.3) | 474 (2.7) | 182 (3.6)† | 85 (5.1)† | 44 (8.1)† | 24 (9.5)† | 13 (2.4) | 274 (2.1)§ | 174 (3.4)† | 122 (5.7)† | 61 (7.1)† | 53 (10.5)† |
| Crude RR | 0.9 [0.7–1.1] | 1 | 1.4 [1.3–1.6] | 2.2 [1.9–2.5] | 3.0 [2.5–3.6] | 4.1 [3.3–5.1] | ||||||
| Adjusted RR** | 0.9 [0.6–1.2] | 1 | 1.3 [1.2–1.5] | 2.1 [1.7–2.4] | 2.3 [1.8–2.9] | 2.8 [2.1–3.6] | p interaction = 0.26 and 0.06 | |||||
| Adjusted RR obtained with fractional polynomials* | 0.7 [0.7–0.7] | 1 | 1.4 [1.4–1.5] | 1.9 [1.7–2.1] | 2.5 [2.1–2.8] | 3.2 [2.6–3.9] | ||||||
| Venous thromboembolism | 51 (0.2) | 50 (0.2) | ||||||||||
| n (%) | 7 (0.3) | 26 (0.2) | 12 (0.2) | 3 (0.2) | 2 (0.4) | 0 (0) | 2 (0.4) | 29 (0.2) | 7 (0.1) | 8 (0.4) | 2 (0.2) | 2 (0.4) |
| Crude RR | 1.9 [0.9–3.9] | 1 | 1.0 [0.6–1.7] | 1.5 [0.8–2.9] | 1.5 [0.5–4.1] | 1.4 [0.3–5.7] | ||||||
| Adjusted RR*** | 1.1 [0.5–2.8] | 1 | 1.1 [0.6–1.8] | 1.5 [0.8–2.8] | 0.9 [0.3–2.6] | 0.9 [0.2–3.8] | p interaction = 0.09 and 0.15 | |||||
| Adjusted RR obtained with fractional polynomials* | 1.0 [0.8–1.1] | 1 | 1.1 [0.9–1.3] | 1.1 [0.8–1.6] | 1.2 [0.7–2.1] | 1.3 [0.6–2.8] | ||||||
Data are n (%); RR: risk ratios.
When interaction exists between cohort and studied outcome, stratified analysis is reported with different RR in each cohort. In the absence of interaction, a single RR is reported and presented in the France group as an RR.
†Tests BMI classes versus BMI reference (normal weight) [only reported for n (%)]; p < 0.05.
§Tests BMI class in Canada versus the same BMI class in France (France is the reference); p < 0.05.
αIncludes preeclampsia, severe preeclampsia and eclampsia.
*Type 1 and Type 2 diabetes were excluded. Adjustment was made for ethnicity, maternal age and prior gestational diabetes.
**Adjusted for ethnicity, maternal age, smoking status, parity, history of hypertensive disorders of pregnancy, chronic hypertension, systemic lupus erythematosus, cardiac disease, inherited thrombophilia, chronic kidney disease, Crohn disease, type 1 diabetes, type 2 diabetes.
***Adjusted for ethnicity, maternal age, inherited thrombophilia and previous thromboembolism event.