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. 2017 Sep 7;7:10906. doi: 10.1038/s41598-017-10653-y

Figure 3.

Figure 3

Ex vivo study to assess the targeting ability of the probe to apoptotic chondrocytes of injured xiphoid. (A) A schematic illustration of ex vivo injured xiphoid model. (B) Ex vivo imaging of injured xiphoid tissue. Probe incubation (0.05 mg/mL) for 2 hours. Scale bar: 2 mm. (C) Quantification analysis (n = 5, Student’s t-test, *p < 0.05). (D) TUNEL staining of injured cartilage explants and control tissue, and near-infrared fluorescence images of injured and healthy (control) xiphoid tissues sections (Scale bar: 100 μm. Arrow heads indicate TUNEL positive cells). (E) Correlation between fluorescence intensity and TUNEL positive chondrocyte number per 1 mm2. Pearson correlation test was performed (Pearson coefficient = 0.9193). All the statistical data were presented as mean ± standard deviation.