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. 2017 Sep 7;7:10801. doi: 10.1038/s41598-017-09790-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Interstitial fibrosis in different regions of the LV. (A) Representative images of Sirius red stained sections and polarized light microscopy from the adjacent, remote and scar tissue of SHAM and MI. (B) Analysis of interstitial fibrosis, and in polarized light collagen type I (red-yellow) and collagen type III (green) in SHAM and MI. Scale bars represent 50 µm. (C) Collagen type I and III mRNA expression in the adjacent and remote myocardium of SHAM and MI. (**p < 0.01: ***p < 0.001) (2-way ANOVA with Bonferroni post hoc test).