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. 2017 Sep 7;7:10936. doi: 10.1038/s41598-017-11119-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heterogeneity of Cells Collected – Proportions of collected CTCs in different bins based upon positivity of surface and intracellular markers from (a) breast cancer patients and (b) prostate cancer patients. (c) Example images of CTCs from a single breast cancer patient. (d) Top panel: Table view of single CTCs identified via their positivity for PSMA and/or EpCAM (top rows) and control cell lines or white blood cells (bottom rows, represents median). Each row represents a single nucleated event and each column represent a channel detecting specified antigen. Color scale is denoted in the bottom, with white representing signal below S/N threshold set based upon controls. Bottom panel: a parallel slide based analysis of the same sample confirmed positive cells and their immunostaining for tumor marker. We detected 45 CTCs from slide-based analysis and 86 from mass cytometry based analysis from a total of 12 mL blood. (CK: cytokeratin, PSMA: prostate specific membrane antigen, PSA: prostate specific antigen).