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. 2017 Sep 7;7:10806. doi: 10.1038/s41598-017-10521-9

Figure 2.

Figure 2

The potency of the H2-RLX and ML290 cAMP response is dependent on the expression level of RXFP1 mRNA. (a) Representative dose-response curves for H2-RLX and ML290 in HEK293 cells transiently transfected with RXFP1 BacMam virus at 0.5%, 5% and 10% v/v. (b) Summary table of average H2-RLX and ML290 pEC50 values in HEK293 cells transiently transfected with RXFP1 BacMam virus at 0.5%, 5% and 10% v/v. (c) Mean relative RXFP1 transcript level, normalized to beta-actin (ACTB) (n = 3), in RXFP1-HEK293 (5% (v/v) BacMam), LX-2 cells and hHSCs p = 0.0002 RXFP1-HEK293 vs LX2 and RXFP1-HEK293 vs hHSC.