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. 2017 Sep 7;7:10806. doi: 10.1038/s41598-017-10521-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Compound ML290 induced modulation of fibrosis related gene transcripts in LX-2 cell line. LX-2 cells were treated with 10 μM or 100 nM of ML290, 100 nM H2-RLX or PBS (control) for 24 h (n = 4). Expression of (a) RXFP1, (b) MMP1, (c) COL1A2 mRNA was quantified by qPCR, normalized to beta-actin (ACTB) and fold changes were calculated as a ratio of values from treated to PBS controls. (d) Investigation of antifibrotic effects using qPCR array to quantify fibrosis related gene transcripts in LX-2 cells treated with 100 µM ML290. mRNA expression was normalized to GAPDH and fold changes were calculated as a ratio of values from treated to PBS controls. (NS not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).