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RXFP1 agonist activity of ML290 structural analogues.
| Compound Name | Chemical Structure | Agonist pEC50 (HEK293-RXFP1) | % H2-RLX Maximum Activity |
|---|---|---|---|
| ML290 |
|
5.1 | 55 |
| Compound 1 |
|
6.0 | 64 |
| Compound 2 |
|
6.0 | 104 |
| Compound 3 |
|
5.3 | 38 |
| Compound 4 |
|
inactive | inactive |
