Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 7;7:10849. doi: 10.1038/s41598-017-11110-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Correction of batch effect in CRC and normal gene expression datasets whilst retaining biological effects. (A,B) PCA plots showing clustering of samples (the two CRC datasets – GSE18088 and GSE23878) after batch correction using correctBATCH (A) and ComBat (B). (C,D) Forest plots from findBATCH show batch (blue) and normal/tumor biological effect (orange) associated with batch corrected data from (C) correctBATCH and (D) ComBat. pPCs are considered significant only if 95% CIs do not include zero. The gPCA p-values of 1.000 and 0.908 for correctBATCH and ComBat, respectively, are shown. (E) A plot showing Pearson correlation between batch-corrected data from correctBATCH and ComBat methods.