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. 2017 Sep 7;7:10846. doi: 10.1038/s41598-017-11458-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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rmTBI does not exaggerate the increase of the duration of LORR. (A) Schematic diagram of the experiments. All the rmTBI mice received the concussion-like head injury once a day from Monday to Friday for 5 uninterrupted weeks, while the control mice received sham treatment. After the 25 repeated head injuries, Morris water maze (MWM) was performed at the 2^nd, 8^th and 12^th week after the last injury, respectively. & represents the time point of MWM and # represents the time point of mice being sacrificed. (B) The duration of LORR was measured after each mTBI (rmTBI) and sham treatment (Control). The number represents the duration of LORR after single mTBI. The values are expressed as mean ± SEM, N = 17/group. *p < 0.05 by two-way ANOVA.