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. 2017 Sep 7;7:10846. doi: 10.1038/s41598-017-11458-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Memory deficits at 2 weeks after the last injury of rmTBI. A Morris water maze test consists of 1 day of visible platform tests, 4 days of hidden platform tests and 1 probe test 24 hours after the last hidden platform test. In the visible platform tests, rmTBI and control mice had similar latency (A) and swimming distance (B) to escape onto the platform. The values were expressed as mean ± SEM, N = 5/group, p > 0.05 by Student’s t-test. In the hidden platform test, mice were trained with 5 trials per day for 4 days. rmTBI mice had longer latency (C) and swimming distance (D) on the 3^rd, 4^th and 5^th day. The values were expressed as mean ± SEM, N = 5/group, *p < 0.05 by ANOVA. (E) In the probe trial, the number of times the rmTBI mice traveled into the platform zone was significantly less than that of the control mice. The values were expressed as mean ± SEM, N = 5/group, *p < 0.05 by Student’s t-test.