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Summary of the key results (a), and schematic diagram depicting the epigenetic mechanism of Arg-induced HIF-1α degradation at the ASS1 promoter as described in the text (b). HIF-1α usually complexes with one β member of the HIF the family (HIF-1β, HIF-2β, and HIF-3β) which is constitutively expressed. For simplicity, we only show HIF-1α at the ASS1 promoter here.
