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. 2017 Sep 7;7:10815. doi: 10.1038/s41598-017-11219-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phospholipid head group selectivity of hGIIE. (a–c) Enzymatic activity of hGIIE determined by isothermal titration calorimetry method: (a) 1, 2-dihexanoyl-sn-glycero-3- phosphor-ethanolamine (DHPE); (b) 1, 2-dihexanoyl-sn-glycero-3-phosphor-rac-1-glycerol (DHPG); (c) 1, 2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC). Heat flows are converted to specific enzyme activities. The raw titration curves are shown in the inserts. Data is fitted to the standard Michaelis-Menten equation, trend line is shown in red. (d–f) Docking model of hGIIE with the phospholipid: (d) hGIIE-DHPE; (e) hGIIE-DHPG; (f) hGIIE-DHPC. Hydrogen bond interaction is indicated by black dash lines, and residues involved are shown as stick.