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. Author manuscript; available in PMC: 2017 Sep 8.
Published in final edited form as: JACC Cardiovasc Imaging. 2016 May 25;9(8):950–961. doi: 10.1016/j.jcmg.2016.01.020

Figure 3. Plaque targeting of 89Zr-HDL nanoparticles in Apoe−/− mice.

Figure 3

A) Comparison between radioactivity content and NIRF intensity (total radiant efficiency, in µW/cm2) in the aortic roots of Apoe−/− (18 weeks on HFD) and wild type B6 mice at 24 h p.i. of 89Zr-AI-HDL and DiR@Zr-AI-HDL (top) and 89Zr-PL-HDL and DiR@Zr-PL-HDL (bottom) (n ≥ 4 per group). B) Autoradiography and NIRF images of whole aortas of Apoe−/− (18 weeks on HFD) and wild type B6 mice at 24 h p.i. of 89Zr-AI-HDL and DiR@Zr-AI-HDL (top) and 89Zr-PL-HDL and DiR@Zr-PL-HDL (bottom). C) Correlation between radioactivity content and NIRF intensity (total radiant efficiency, in µW/cm2) in the aortic roots of Apoe−/− (18 weeks on HFD) and wild type B6 mice at 24 h p.i. of 89Zr-AI-HDL and DiR@Zr-AI-HDL (top) and 89Zr-PL-HDL and DiR@Zr-PL-HDL (bottom) (n ≥ 4 per group). * P < 0.05.