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. 2017 Sep 7;7:10773. doi: 10.1038/s41598-017-11482-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Combined role of CEACAM6 expression and distant metastasis in predicting overall survival in patients with gastric cancer. Kaplan-Meier curves of OS according to CEACAM6 expression in patients (A) without and (B) with lymph node metastasis. Images of CEACAM6 and HE staining in tumor and adjacent tissues in (C) early-stage and (D) advanced-stage GC. In panel 1, CEACAM6-positive tumor cells are apparent in the vascular and interstitial space of adjacent tissues. In panel 2, signet ring cancer cells are apparent with strong CEACAM6 staining and tumor cell invasion through the interstitial space and into adjacent tissues (black arrow: CEACAM6-positive tumor cells, red arrow: normal gastric glands).