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. 2017 Sep 7;7:10773. doi: 10.1038/s41598-017-11482-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Combined role of CEACAM6 expression and chemotherapy with 5-fluorouracil in predicting the overall survival in patients with gastric cancer. Kaplan-Meier curves of overall survival according to CEACAM6 expression in patients who were treated with adjuvant chemotherapy (A) with and (B) without 5-FU. (C) CEACAM6 overexpression inhibits apoptosis in MKN45 and SGC7901 GC cell lines. (D,E) CEACAM6 overexpression affects apoptosis in GC cell lines treated with different concentrations of 5-FU (0.0, 5.0, and 10.0 µg/mL). (F) Dissociated tumor cells (black arrow) exhibit strong positive staining for CEACAM6. (G) CEACAM6 overexpression inhibits anoikis in GC cell lines.