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. 2017 Sep 7;7:10773. doi: 10.1038/s41598-017-11482-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Proposed mechanism for CEACAM6 function in early- and advanced-stage gastric cancer. (A) In early-stage GC, immunocytes are abundant and the body’s immune response is very strong. Immunocytes expressing CEACAM6 are more likely to interact with CEACAM6-positive tumor cells through homophilic and heterophilic intercellular interactions. Therefore, the majority of tumor cells are suppressed or killed. Thus, high CEACAM6 expression is associated with better overall survival in patients with early-stage GC. (B) Immunocytes were absent in advanced-stage GC. However, CEACAM6 expression is increased, which promotes tumor metastasis, anti-apoptosis, and angiogenesis. Consequently, high CEACAM6 expression is associated with a poor overall survival in patients with advanced-stage GC.