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Molecular architecture of APP. Schematic representation of human APP isoforms and the APP-like proteins (APLP), APLP1 and APLP2. APP isoforms range in size from 695 to 770 amino acids. The most abundant form in brain is APP695, which lacks a Kunitz type protease inhibitor sequence in its ectodomain. APP751 and APP770 contain the Kunitz type serine protease inhibitory domain (KPI) are mainly expressed on the surface of peripheral cells and platelets.
