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. 2017 Jul 10;38(9):1205–1235. doi: 10.1038/aps.2017.28

Table 3. Summary of small molecule inhibitors of amyloid oligomers for the treatment of Alzheimer's disease.

Name Targets Effects Ref
2-Amino-4-chlorophenol Blocks Aβ oligomerization and fibrillization Blocks neurotoxicity 259
4-Aminophenol Blocks Aβ oligomerization and fibrillization Blocks neurotoxicity 259
4-Aminoanisole Blocks Aβ oligomerization and fibrillization Blocks neurotoxicity 259
3,4-Dihydroxybenzoic acid Blocks Aβ oligomerization and fibrillization Blocks neurotoxicity 259
2-Hydroxy-3-ethoxy benzoaldehyde Blocks Aβ oligomerization and fibrillization Blocks neurotoxicity 259
Resveratrol Remodels soluble oligomers and amyloid fibrils into nontoxic species Attenuates cognitive deterioration 351
NQTrp Inhibits the fibrillization of amyloidogenic proteins Reduces Aβ aggregation 269,270
ClNQTrp Inhibits the fibrillization of amyloidogenic proteins Reduces Aβ aggregation 269,270
Coumarin Inhibits Aβ aggregation Prevents cognitive decline 266
Furosemide Inhibits Aβ oligomerization Increases the life span 273
D737 Inhibits Aβ formation Prevents toxicity and ROS accumulation 274