Table 7. Summary of β-degrading proteases (AβDPs) for the treatment of Alzheimer's disease.

Name	Targets	Effects	Ref
NEP	Endogenous regulator of Aβ	Degrades Aβ oligomers	306
NEP2	Homologues of NEP	Degradation of Aβ	307
hMMEL	Homologues of NEP	Degradation of Aβ	308
ECE1	Endothelin converting enzyme	Endogenous regulator of Aβ	142,309
ECE2	Endothelin converting enzyme	Endogenous regulator of Aβ	142,309
ACE	Endothelin converting enzyme	Endogenous regulator of Aβ	142,309
Plasmin	Serine protease	Degrades both monomeric and fibrillar forms of Aβ	150,355
Acylpeptide hydrolase	Serine protease	Degrades secreted Aβ dimmers and trimers	356,357
Cathepsin D	Cysteine protease	Degradation of Aβ	358
BACE1	Cysteine protease	Degradation of Aβ	291
BACE2	Cysteine protease	Degradation of Aβ	359
Cathepsin B	Cysteine protease	Degradation of Aβ	282