Table 9. Summary of other blockers for the treatment of Alzheimer's disease.

Name	Targets	Effects	Ref
Liraglutide (Victoza)	A diabetes drug	Cognitive benefits, reduced inflammatory response and an increase of young neurons	319
β-Sheet breaker	Binds Aβ and destabilizes its structure	Inhibits oligomer or amyloid formation	320,321
MRS2481	Small molecule blocker of Abeta channel	Protects neurons from Aβ induced toxicity	322
MRS2485	Small molecule blocker of Abeta channel	Protects neurons from Aβ induced toxicity	322
Bexarotene	Inhibits the binding of cholesterol to Aβ and prevents calcium-permeable amyloid pore formation	Anti-Alzheimer	323
Verapamil	Voltage-gated calcium channel blocker	Protects neurons from Aβ-induced toxicity	324
Diltiazem	Voltage-gated calcium channel blocker	Protects neurons from Aβ-induced toxicity	324
Isradipine	Voltage-gated calcium channel blocker	Protects neurons from Aβ-induced toxicity	324
Nimodipine	Voltage-gated calcium channel blocker	Protects neurons from Aβ-induced toxicity	324
Huperzine A	A novel lycopodium alkaloid	Neuroprotective effects	326,327
Arctigenin	Inhibits Aβ production and promotes Aβ clearance	Ameliorates memory impairment	330
2,2′,4′-trihydroxychalcone (TDC)	Represses beta-cleavage of APP and production of Aβ	Improves the memory impairment	328
Bis(7)-cognitin	Inhibition of AChE, NMDA receptor, nitric oxide synthase, and amyloid precursor protein/beta-amyloid cascade	Neuroprotective effects	329
Clioquinol	Inhibits metal-ion binding to Aβ	Inhibits Aβ deposition	331
Idalopirdine	5-HT6 receptor antagonist	In combination with a cholinesterase inhibitor may increase the cognitive function	325
Azeliragon	RAGE inhibitor	Mediates transport of the Aβ peptide into the brain	332
Encenicline	α7-nAChR inhibitor	Restores memory function	333
Nilvaldipine	Calcium antagonist	Cognition improvement	334