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C33(S) could alleviate cardiac hypertrophic responses in vitro. Cardiomyocytes were pre-incubated by C33(S) and PF-7943 for 1 h followed by PE treatment or not. (A, B) Cell surface areas were measured (cell surface area, ×400). (C, D) The mRNA and protein levels of fetal genes were measured. C33(500): C33(S) 500 nmol/L, C33(50): C33(S) 50 nmol/L, PF-7943(2): PF-7943 2 μmol/L. *P<0.05, **P<0.01 vs control group. #P<0.05, ##P<0.01 vsPE group. n=5. Data were expressed as mean±SEM.
