Table 1. The effect of Kv7/KCNQ/M-channel modulators XE991, retigabine and QO58L on membrane properties of PFC layer V pyramidal neurons.
| Resting membrane potential (Vm, mV) | Input resistance (Rin, MΩ) | mAHP amplitude (mV) | |
|---|---|---|---|
| Control | −69.1±0.9 (n=10) | 145.5±12.1 (n=10) | 3.5±0.2 (n=10) |
| XE991 | −64.2±1.1** (n=10) | 165.8±11.9 (n=10) | 3.4±0.3 (n=10) |
| Control | −62.1±1.3 (n=7) | 207.9±17.6 (n=7) | 2.9±0.4 (n=7) |
| Retigabine | −62.2±1.4 (n=7) | 217.4±27.8 (n=7) | 4.9±0.7* (n=7) |
| Control | −66.8±1.3 (n=10) | 218.4±28.5 (n=10) | 3.6±0.3 (n=10) |
| QO58L | −66.1±1.5 (n=10) | 186.3±35.0 (n=10) | 3.0±0.3 (n=10) |
Resting membrane potential (Vm), input resistance (Rin), and mAHP amplitude of PFC layer V pyramidal neurons in the control condition and in the presence of XE991 (40 μmol/L), retigabine (10 μmol/L) and QO58L (10 μmol/L). Data are presented as mean±SEM. n=7–10,
*P<0.05,
**P<0.01.