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. 2017 Jun 12;38(9):1297–1304. doi: 10.1038/aps.2017.73

Figure 3.

Figure 3

miR-4458 suppresses the proliferation of lung cancer cells through Lin28B. (A and B) EdU stain assay showed that miR-4458 significantly inhibited the proliferation of A549 cells, whereas anti-miR-4458 significantly promoted the proliferation of A549 cells. Furthermore, knockdown of Lin28B by siRNA transfection significantly reversed the effect of anti-miR-4458-induced promotion of proliferation in A549 cells. (C) Colony-formation assays showed that miR-4458 significantly inhibited the colony-formation efficiency of A549 cells, whereas anti-miR-4458 significantly promoted the efficiency of A549 cells, which could be reversed by si-Lin28B. (D) The transfection efficiency of miR-4458, anti-miR-4458 and si-Lin28B. *P<0.05; **P<0.01.